Regulatory sequences of the H19 gene in DNA based therapy of bladder cancer
نویسندگان
چکیده
Patricia Ohana, Ofer Gofrit, Suhail Ayesh, Wasif Al-Sharef, Aya Mizrahi, Tatiana Birman, Tamar Schneider, Imad Matouk, Nathan de Groot, Eli Tavdy, A. Ami Sidi, and Abraham Hochberg Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel Department of Urology, Hadassah University Hospital, Jerusalem, Israel Department of Urologic Surgery, The Wolfson Medical Center, Holon, and Sackler Faculty of Medicine Tel Aviv, University, Israel Molecular Genetics Laboratory, Makassed Islamic Charitable Hospital, Jerusalem, Israel __________________________________________________________________________________
منابع مشابه
The H19-IGF2 Role in Bladder Cancer Biology and DNA-Based Therapy
The H19-IGF2 locus within the imprinted cluster of the human chromosome 11, has been implicated in a variety of disorders and cancer pre-disposition including bladder cancer. BBN induced bladder cancer model in rats has identified both H19 and IGF2 among differentially expressed genes that are induced in response to carcinogen exposure. In this chapter, the role of both H19 and IGF2 genes in ca...
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BACKGROUND The human IGF2-P4 and H19 promoters are highly active in a variety of human cancers, while existing at a nearly undetectable level in the surrounding normal tissue. Single promoter vectors expressing diphtheria toxin A-fragment (DTA) under the control regulation of IGF2-P4 or H19 regulatory sequences (IGF2-P4-DTA and H19-DTA) were previously successfully used in cell lines, animal mo...
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Pancreatic cancer is the eighth most common cause of death from cancer in the world, for which palliative treatments are not effective and frequently accompanied by severe side effects. We propose a DNA-based therapy for pancreatic cancer using a nonviral vector, expressing the diphtheria toxin A chain under the control of the H19 gene regulatory sequences. The H19 gene is an oncofetal RNA expr...
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